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Unified single-cell analysis of testis gene regulation and pathology in 5 mouse strains

2018-08-16

Abstract excerpt

By removing the confounding factor of cellular heterogeneity, single cell genomics can revolutionize the study of development and disease, but methods are needed to simplify comparison among individuals. To develop such a framework, we assayed the transcriptome in 62,600 single cells from the testes of wildtype mice, and mice with gonadal defects due to disruption of the genes Mlh3 , Hormad1 , Cul4a or Cnp . T...

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Literature Corpus work
95be7212-9dce-593b-8da0-6c9fd7c4be1a
DOI
10.1101/393769
Open publication

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Unified single-cell analysis of testis gene regulation and pathology in 5 mouse strainsDOI 10.1101/393769
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