Article
Dissecting cell identity via network inference and in silico gene perturbation.
Nature - 1 Feb 2023
Kamimoto Kenji, Stringa Blerta, Hoffmann Christy M, Jindal Kunal, Solnica-Krezel Lilianna, Morris Samantha A
Abstract excerpt
Cell identity is governed by the complex regulation of gene expression, represented as gene-regulatory networks1. Here we use gene-regulatory networks inferred from single-cell multi-omics data to perform in silico transcription factor perturbations, simulating the consequent changes in cell identity using only unperturbed wild-type data. We apply this machine-learning-based approach, CellOracle, to...
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