Gene-based therapy in lipid management: the winding road from promise to practice

doi:10.1080/13543784.2020.1757070

Article

Gene-based therapy in lipid management: the winding road from promise to practice

29 Apr 2020

Abstract excerpt

INTRODUCTION: Cardiovascular disease (CVD) is a leading cause of morbidity and mortality. High plasma low-density lipoprotein cholesterol (LDL-C) levels are a key CVD-risk factor. Triglyceride-rich remnant particles and lipoprotein(a) (Lp[a]) are also causally related to CVD. Consequently, therapeutic strategies for lowering LDL-C and triglyceride levels are widely used in routine clinical practice; however,...

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