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Regulation of CD19 CAR-T cell activation based on an engineered downstream transcription factor

26 Apr 2023

Abstract excerpt

CAR-T cells present a highly effective therapeutic option for several malignant diseases, based on their ability to recognize the selected tumor surface marker in an MHC-independent manner. This triggers cell activation and cytokine production, resulting in the killing of the cancerous cell presenting markers recognized by the chimeric antigen receptor. CAR-T cells are highly potent serial killers that may cause...

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PMID: 37223115
DOI: 10.1016/j.omto.2023.04.005

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