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Enhancing the safety of CAR-T cell therapy: Synthetic genetic switch for spatiotemporal control

23 Feb 2024

Abstract excerpt

Chimeric antigen receptor T (CAR-T) cell therapy is a promising and precise targeted therapy for cancer that has demonstrated notable potential in clinical applications. However, severe adverse effects limit the clinical application of this therapy and are mainly caused by uncontrollable activation of CAR-T cells, including excessive immune response activation due to unregulated CAR-T cell action time, as well as...

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PMID: 38394207
DOI: 10.1126/sciadv.adj6251

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