Article

Single-cell RNA sequencing reveals dysregulated fibroblast subclusters in prurigo nodularis

2023-08-22

Abstract excerpt

<h4>Background: </h4> Prurigo nodularis (PN) is an intensely pruritic, inflammatory skin disease with a poorly understood pathogenesis. <h4>Methods: </h4>: We performed single-cell transcriptomic profiling of 28,695 lesional and non-lesional PN cells. <h4>Results: </h4>: Lesional PN has increased dysregulated fibroblasts (FBs) and myofibroblasts. FBs in lesional PN were shifted towards a cancer-associated fibrob...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e3529863-407c-55ec-bb22-236c1ae5365f
DOI: 10.22541/au.169267951.15020752/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell RNA sequencing reveals dysregulated fibroblast subclusters in prurigo nodularisDOI 10.22541/au.169267951.15020752/v1Read

Single-cell RNA sequencing reveals dysregulated fibroblast subclusters in prurigo nodularisSemantic proximity Read

Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseasesSemantic proximity Read

Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseasesSemantic proximity Read

Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases.Semantic proximity Read

New insight into the role of fibroblasts in the epithelial immune microenvironment in the single-cell eraSemantic proximity Read

Somatic mutations reveal hyperactive Notch signaling in prurigo nodularis.Semantic proximity Read

Somatic mutations reveal hyperactive Notch signaling and racial disparities in prurigo nodularisSemantic proximity Read

TNC+ fibroblasts involve in skin inflammation via neuro-immune and interacting with T cellsSemantic proximity Read

Unraveling the role of CLOCK gene in fibrotic skin diseases: insights from single-cell RNA sequencing analysisSemantic proximity Read

Comprehensive Transcriptomic Profiling of Nonatopic Prurigo Nodularis in Korean Patients Reveals Il-22-driven Epidermal Stress and Neuro-immuno-fibrotic Remodelling.Semantic proximity Read

Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulationSemantic proximity Read

A scRNA-seq atlas of chronic inflammatory skin diseasesSemantic proximity Read