Article
Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases.
Med (New York, N.Y.) - 8 Jul 2022
Korsunsky Ilya, Wei Kevin, Pohin Mathilde, Kim Edy Y, Barone Francesca, Major Triin, Taylor Emily, Ravindran Rahul, Kemble Samuel, Watts Gerald F M, Jonsson A Helena, Jeong Yunju, Athar Humra, Windell Dylan, Kang Joyce B, Friedrich Matthias, Turner Jason, Nayar Saba, Fisher Benjamin A, Raza Karim, Marshall Jennifer L, Croft Adam P, Tamura Tomoyoshi, Sholl Lynette M, Vivero Marina, Rosas Ivan O, Bowman Simon J, Coles Mark, Frei Andreas P, Lassen Kara, Filer Andrew, Powrie Fiona, Buckley Christopher D, Brenner Michael B, Raychaudhuri Soumya
Abstract excerpt
BACKGROUND: Pro-inflammatory fibroblasts are critical for pathogenesis in rheumatoid arthritis, inflammatory bowel disease, interstitial lung disease, and Sjögren's syndrome and represent a novel therapeutic target for chronic inflammatory disease. However, the heterogeneity of fibroblast phenotypes, exacerbated by the lack of a common cross-tissue taxonomy, has limited our understanding of which pathways are...
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