Article

Single-cell RNA sequencing reveals dysregulated fibroblast subclusters in prurigo nodularis

2023-01-31

Abstract excerpt

Prurigo nodularis (PN) is an intensely pruritic, chronic inflammatory skin disease that disproportionately affects black patients. However, the pathogenesis of PN is poorly understood. We performed single-cell transcriptomic profiling, ligand receptor analysis and cell trajectory analysis of 28,695 lesional and non-lesional PN skin cells to uncover disease-identifying cell compositions and genetic characteristics....

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Literature Corpus work: 745c6724-6d2d-50ba-b604-75e95e05d8cb
DOI: 10.1101/2023.01.29.526050

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