Article

Elucidation of the molecular mechanisms underlying the ability of C. elegans pharynx to recognize as toxicant the soluble, pre-fibrillar assemblies of the amyloidogenic proteins

2019-01-01

Abstract excerpt

Immunoglobulin light chain amyloidosis (AL) is the most common form of systemic amyloidosis in which a plasma-cell dyscrasia results in the overproduction of amyloidogenic immunoglobulin light chains (LC). Although LC organize in extracellular deposits in different target organs, approximately 75% of patients manifest heart involvement at presentation, with a median survival of only 6 months if chemotherapy fails...

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Literature Corpus work: 2e9c71a3-1455-5746-a4d6-b85d87f122a3
DOI: 10.21954/ou.ro.0000e614

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