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Fast fluorescence lifetime imaging reveals the aggregation processes of α-synuclein and polyglutamine in aging <i>Caenorhabditis elegans</i>

2018-09-11

Abstract excerpt

The nematode worm Caenorhabditis elegans has emerged as an important model organism to study the molecular mechanisms of protein misfolding diseases associated with amyloid formation because of its small size, ease of genetic manipulation and optical transparency. Obtaining a reliable and quantitative read-out of protein aggregation in this system, however, remains a challenge. To address this problem, we here pr...

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Literature Corpus work
7d98394f-fc89-5d6f-a969-3d5a45eda185
DOI
10.1101/414714
Open publication

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