Article

Modeling immunoglobulin light chain amyloidosis in <i>Caenorhabditis elegans</i>

2024-07-09

Abstract excerpt

Cardiomyopathy determines the prognosis of patients with immunoglobulin light chain (AL) amyloidosis, a rare systemic disease caused by the misfolding and deposition of monoclonal light chains (LCs). The reasons underlining their cardiac tropism remain unknown, and an animal model recapitulating the main pathological features of AL amyloidosis is instrumental. Taking advantage of the similarities between the verte...

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Literature Corpus work: 36fcd842-8cc5-537f-964c-801fa1bab262
DOI: 10.1101/2024.07.05.602215

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