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Article

Polygenic Hyperlipidemias and Coronary Artery Disease Risk.

Circulation. Genomic and precision medicine - 1 Apr 2020

Ripatti Pietari, Rämö Joel T, Mars Nina J, Fu Yu, Lin Jake, Söderlund Sanni, Benner Christian, Surakka Ida, Kiiskinen Tuomo, Havulinna Aki S, Palta Priit, Freimer Nelson B, Widén Elisabeth, Salomaa Veikko, Tukiainen Taru, Pirinen Matti, Palotie Aarno, Taskinen Marja-Riitta, Ripatti Samuli

Abstract excerpt

BACKGROUND: Hyperlipidemia is a highly heritable risk factor for coronary artery disease (CAD). While monogenic familial hypercholesterolemia associates with severely increased CAD risk, it remains less clear to what extent a high polygenic load of a large number of LDL (low-density lipoprotein) cholesterol (LDL-C) or triglyceride (TG)-increasing variants associates with increased CAD risk. METHODS: We derived...

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Source

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Identifiers

PMID: 32154731
DOI: 10.1161/CIRCGEN.119.002725
PMCID: PMC7176338

Genes

CAD
TG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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