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Article

Deep representation learning improves prediction of LacI-mediated transcriptional repression.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jul 2021

Garruss Alexander S, Collins Katherine M, Church George M

Abstract excerpt

Recent progress in DNA synthesis and sequencing technology has enabled systematic studies of protein function at a massive scale. We explore a deep mutational scanning study that measured the transcriptional repression function of 43,669 variants of the Escherichia coli LacI protein. We analyze structural and evolutionary aspects that relate to how the function of this protein is maintained, including an in-depth...

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Identifiers

PMID: 34187888
DOI: 10.1073/pnas.2022838118
PMCID: PMC8271634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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