Article

Frizzled-4 regulates β-catenin in endothelial cells exposed to disturbed flow via an atypical Wnt pathway leading to proinflammatory activation and increased permeability

2021-11-12

Abstract excerpt

<h4>Objective</h4> Endothelial cells are regulated by hemodynamic wall shear stress and multidirectional shear stress is known to promote endothelial dysfunction, although the molecular mechanisms are poorly defined. Wnt pathways play an important role in non-vascular mechanoresponsive cells. Here we investigated their role in endothelial mechanosignalling and endothelial dysfunction. <h4>Approach & Results</h4>...

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Literature Corpus work: 7dc3468f-0e33-58f8-8205-ad1480bc37d0
DOI: 10.1101/2021.11.12.468370

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