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Article

Impairment of neuronal activity occurs at the early stages of the aggregation cascade of Aβ1-42 and mutant Tau.

Disease models & mechanisms - 1 Mar 2026

Hirsch Franziska, F Läubli Nino, Kelkar Anushree, Sleiman Mira, Woitzat Yvonne, Gallrein Christian, Gumz Vanessa, Kalsi Gurleen Kaur, Fernandez-Villegas Ana, Schierle Gabriele S Kaminski, Kirstein Janine

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disease that is characterized by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary Tau tangles, ultimately leading to brain atrophy and death. To elucidate the relationship between the aberrant folding and aggregation of Aβ and mutant Tau and neuronal function, we monitored neuronal activity in C. elegans AD models across age. For that, we...

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PMID: 41725344
DOI: 10.1242/dmm.052295
PMCID: PMC13072132

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