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Article

Integrative Multivariate Genomics Identifies Shared Epithelial-Immune and Cytokine-Regulatory Mechanisms Across Major Chronic Lung Diseases.

International journal of molecular sciences - 2 Aug 2026

Liao Chung-Chih, Liao Ke-Ru, Li Jung-Miao

Abstract excerpt

Chronic lung diseases, including asthma, chronic obstructive pulmonary disease, bronchiectasis, and idiopathic pulmonary fibrosis, are clinically distinct but share epithelial injury, host-defense, inflammatory, and remodeling processes. We integrated European-ancestry genome-wide association study (GWAS) summary statistics for these four diseases using genomic structural equation modeling to construct a...

Topics

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Chronic Disease
Cytokines
GSDMB gene
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Open in PubMed Open full text

Identifiers

PMID: 42589600
DOI: 10.3390/ijms27156946
PMCID: PMC13466783

Genes

CLEC16A
GSDMB
IL18R1
IL18RAP
IL1R1
ORMDL3
SMAD3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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