Article
Tissue-resident immune cells drive genetic risk in autoimmune and lung diseases.
Nature immunology - 1 Sept 2026
Schmiedel Benjamin J, Gonzalez-Colin Cristian, Fajardo-Rosas Vicente, Rocha Job, Simon Hayley, Ottensmeier Johannes, Ramírez-Bernabé Ignacio E, Cano April, De la Cruz Castillo Angel, Márquez-Gómez Elizabeth, Ha Brendan, Greenbaum Jason A, Chudley Lindsey, Cave Judith, Alzetani Aiman, Woo Edwin, Shackcloth Michael, Chee Serena J, Chandra Vivek, Kronenberg Mitchell, Peters Bjoern, Ottensmeier Christian H, Ganesan Anusha-Preethi, Vijayanand Pandurangan
Abstract excerpt
Common genetic variants are associated with risk of lung and autoimmune diseases. However, we have a limited understanding of the pathological effects of these disease variants, specifically in tissue-resident immune cells at the frontier of infection and disease in the lung. To address this, we performed single-cell expression quantitative trait locus (eQTL) analysis across 29 distinct immune cell subsets...
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