Article

Tryptophan metabolite atlas uncovers organ, age, and sex-specific variations

2024-12-23

Abstract excerpt

<h4>ABSTRACT</h4> Although tryptophan (Trp) is the largest and most structurally complex amino acid, it is the least abundant in the proteome. Its distinct indole ring and high carbon content enable it to generate various biologically active metabolites such as serotonin, kynurenine (Kyn), and indole-3-pyruvate (I3P). Dysregulation of Trp metabolism has been implicated in diseases ranging from depression to cance...

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Literature Corpus work: 7d88d41f-79a1-5411-8590-f152ad66becd
DOI: 10.1101/2024.12.23.630041

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