Back to search

Article

SIRT6 regulates Tryptophan catabolism preventing metabolite imbalance and neurodegeneration

2024-08-01

Abstract excerpt

<title>Abstract</title> <p> In the brain, tryptophan byproducts are involved in the biosynthesis of proteins, energy-rich molecules (e.g., NAD <sup>+</sup> ), and neurotransmitters (serotonin and melatonin). Impaired tryptophan catabolism, seen in aging, neurodegeneration and psychiatric diseases affects mood, learning, and sleep; however, the reasons for those impairments remain unknown. Our results from cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c24298c5-3936-55d3-8d21-0039c5de3e5c
DOI
10.21203/rs.3.rs-4588896/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
SIRT6 regulates Tryptophan catabolism preventing metabolite imbalance and neurodegenerationDOI 10.21203/rs.3.rs-4588896/v1
SIRT6 is a key regulator of mitochondrial function in the brainSemantic proximity
Tryptophan metabolite atlas uncovers organ, age, and sex-specific variationsSemantic proximity
SIRT6 is a key regulator of mitochondrial function in the brainSemantic proximity
SIRT6 is a key regulator of mitochondrial function in the brainSemantic proximity
Melatonin and sirtuins: A “not‐so unexpected” relationshipSemantic proximity
Tryptophan metabolism as a target in gut microbiota, ageing and kidney diseaseSemantic proximity
Redefining Roles: A Paradigm Shift in Tryptophan-Kynurenine Metabolism for Innovative Clinical ApplicationsSemantic proximity
Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2,3-dioxygenase (IDO), a novel target in cancer diseaseSemantic proximity
Loss of SIRT 2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalanceSemantic proximity
The role of melatonin in epigenetic regulation of various diseases.Semantic proximity
The Kynurenine Pathway as a Convergent Hub Linking Toll-Like Receptor Signaling, Environmental Exposures, and Gut–Brain Axis Dysfunction in Neurodegenerative DiseasesSemantic proximity
3-hydroxyanthranilic acid – a new metabolite for healthy lifespan extensionSemantic proximity
Select a neighboring publication to make it the new centre.