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Tryptophan metabolism as a target in gut microbiota, ageing and kidney disease

23 Jun 2025

Abstract excerpt

Aromatic amino acid tryptophan metabolism, particularly three main metabolism pathways including kynurenine, serotonin and indole-derived pathways are under the direct or indirect modulation of host-microbiota crosstalk in human physiology. Tryptophan metabolism is involved in the regulation of aging, immunity and intestinal homeostasis. Dysregulation of tryptophan metabolism ranging from bowel disease to kidney...

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PMID: 40765836
DOI: 10.7150/ijbs.115359

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