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Article

Towards an Integrative Understanding of tRNA Aminoacylation-Diet-Host-Gut Microbiome Interactions in Neurodegeneration.

Nutrients - 26 Mar 2018

Paley Elena L, Perry George

Abstract excerpt

Transgenic mice used for Alzheimer's disease (AD) preclinical experiments do not recapitulate the human disease. In our models, the dietary tryptophan metabolite tryptamine produced by human gut microbiome induces tryptophanyl-tRNA synthetase (TrpRS) deficiency with consequent neurodegeneration in cells and mice. Dietary supplements, antibiotics and certain drugs increase tryptamine content in vivo. TrpRS...

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Identifiers

PMID: 29587458
DOI: 10.3390/nu10040410
PMCID: PMC5946195

Genes

WARS2

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