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The tryptophan metabolic pathway of the microbiome and host cells in health and disease

13 Jun 2024

Abstract excerpt

The intricate and dynamic tryptophan (Trp) metabolic pathway in both the microbiome and host cells highlights its profound implications for health and disease. This pathway involves complex interactions between host cellular and bacteria processes, producing bioactive compounds such as 5-hydroxytryptamine (5-HT) and kynurenine derivatives. Immune responses to Trp metabolites through specific receptors have been...

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PMID: 38869080
DOI: 10.1093/intimm/dxae035

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