Article

Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells induce Tfh differentiation

2024-10-14

Abstract excerpt

<title>Abstract</title> NLRP3 inflammasome activation depends on stress-induced production of oxidized mitochondrial DNA (Ox-mtDNA) fragments that enter the cytoplasm to bind NLRP3 and activate caspase-1. Along with pro-IL-1β processing, caspase-1 generates gasdermin D pores that result in circulatory mtDNA release. Elevated amounts of circulating cell-free (ccf)-mtDNA, which is likely to be oxidized, were doc...

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Literature Corpus work: 874a1f4f-f5e5-5c60-9263-e13151a78ba2
DOI: 10.21203/rs.3.rs-5194985/v1

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