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Decoding mitochondrial DNA damage and repair associated with H. pylori infection

21 Jan 2025

Abstract excerpt

Mitochondrial genomic stability is critical to prevent various human inflammatory diseases. Bacterial infection significantly increases oxidative stress, driving mitochondrial genomic instability and initiating inflammatory human disease. Oxidative DNA base damage is predominantly repaired by base excision repair (BER) in the nucleus (nBER) as well as in the mitochondria (mtBER). In this review, we summarize the...

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PMID: 39906209
DOI: 10.3389/fcimb.2024.1529441

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