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Article

A New Perspective on the Origin of DNA Double-Strand Breaks and Its Implications for Ageing.

Genes - 26 Jan 2021

Tripathy Bhabesh Kumar, Pal Kavita, Shabrish Snehal, Mittra Indraneel

Abstract excerpt

It is estimated that 10-50 DNA double-strand breaks (DSBs) occur in a nucleated human cell per cell cycle. We reviewed the present state of knowledge and hypothesized that the currently accepted mechanisms cannot explain such high frequency of DSBs occurring daily under normal physiological conditions. We propose an alternative model that implicates illegitimate genomic integration into healthy cells of cell-free...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33530310
DOI: 10.3390/genes12020163
PMCID: PMC7912064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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