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Article

<i>Ogg1</i> -Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis

6 Jul 2016

Abstract excerpt

RATIONALE: Activation of NLRP3 (nucleotide-binding domain and leucine-rich repeat pyrin domain containing 3) inflammasome-mediating interleukin (IL)-1β secretion has emerged as an important component of inflammatory processes in atherosclerosis. Mitochondrial DNA (mtDNA) damage is detrimental in atherosclerosis, and mitochondria are central regulators of the nucleotide-binding domain and leucine-rich repeat pyrin...

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PMID: 27384322
DOI: 10.1161/circresaha.116.308362

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