Article

Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal

2024-03-02

Abstract excerpt

<h4>ABSTRACT</h4> The persistence of HIV-1 in long-lived latent reservoirs during suppressive antiretroviral therapy (ART) remains one of the principal barriers to a functional cure. Blocks to transcriptional elongation play a central role in maintaining the latent state, and several latency reversal strategies focus on the release of positive transcription elongation factor b (P-TEFb) from sequestration by negat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7d52b0b4-2106-536e-8dab-c03a77854f78
DOI: 10.1101/2024.03.01.582881

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversalDOI 10.1101/2024.03.01.582881Read

Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latencySemantic proximity Read

The role of latency reversal in HIV cure strategiesSemantic proximity Read

Breaking the Silence: Regulation of HIV Transcription and Latency on the Road to a CureSemantic proximity Read

HIV-1 Latency and Viral Reservoirs: Existing Reversal Approaches and Potential Technologies, Targets, and Pathways Involved in HIV Latency StudiesSemantic proximity Read

Clearance of HIV infection by selective elimination of host cells capable of producing HIVSemantic proximity Read

Lost in Transcription: Molecular Mechanisms that Control HIV LatencySemantic proximity Read

Targeting CDK12/CYCLIN K induces HIV gene activation and latency reversal which is mediated by P-TEFbSemantic proximity Read

Forging a Functional Cure for HIV: Transcription Regulators and InhibitorsSemantic proximity Read

The Current Status of Latency Reversing Agents for HIV-1 RemissionSemantic proximity Read

HIV latency: experimental systems and molecular modelsSemantic proximity Read

A broad drug arsenal to attack a strenuous latent HIV reservoirSemantic proximity Read

Post-Transcriptional HIV-1 Latency: A Promising Target for Therapy?Semantic proximity Read