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Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency

15 Jan 2019

Abstract excerpt

The establishment of HIV-1 latency gives rise to persistent chronic infection that requires life-long treatment.To reverse latency for viral eradiation, the HIV-1 Tat protein and its associated ELL2-containing Super Elongation Complexes (ELL2-SECs) are essential to activate HIV-1 transcription.Despite efforts to identify effective latency-reversing agents (LRA), avenues for exposing latent HIV-1 remain...

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PMID: 30645648
DOI: 10.1371/journal.ppat.1007498

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