Article

Targeting CDK12/CYCLIN K induces HIV gene activation and latency reversal which is mediated by P-TEFb

2026-02-13

Abstract excerpt

The administration of antiretroviral therapy has successfully suppressed the replication of Human immunodeficiency virus and substantially inhibited viral infection. However, HIV still persists in long-lived infected cell reservoirs that are resistant to therapy and to immune clearance, therefore a barrier for elimination of infection. HIV gene expression is tightly regulated by the cellular transcription machiner...

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Literature Corpus work: 3c4c5953-a8a9-5895-bf46-ec4ff489057d
DOI: 10.64898/2026.02.10.705011

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