CREB-PGC1α-UCP2 Axis Plays a Critical Role in AML Progression, Offering Potential Therapeutic Targets

Abstract excerpt

Acute myeloid leukemia (AML) is an aggressive hematological malignancy characterized by the uncontrolled proliferation of immature myeloid cells and poor clinical outcomes, particularly in patients with relapsed or refractory disease. Increasing evidence suggests that metabolic reprogramming and mitochondrial adaptation play crucial roles in supporting leukemic cell survival, proliferation, and resistance to thera...

Topics

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• Acute Myeloid Leukemia Research
• Adipose Tissue and Metabolism
• Cancer, Hypoxia, and Metabolism
• Histone Deacetylase Inhibitors Research
• Metabolism, Diabetes, and Cancer
• Mitochondrial Function and Pathology
• Peroxisome Proliferator-Activated Receptors
• Protein Degradation and Inhibitors

Identifiers and source

Literature Corpus work

7d4e26f8-85bf-5731-abc3-6a8ebe37831b

DOI

10.20944/preprints202606.1760.v1