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Article

GFI1B acts as a metabolic regulator in hematopoiesis and acute myeloid leukemia

8 Jul 2022

Abstract excerpt

Recent studies highlighted the role of transcription factors in metabolic regulation during hematopoiesis and leukemia development. GFI1B is a transcriptional repressor that plays a critical role in hematopoiesis, and its expression is negatively related to the prognosis of acute myeloid leukemia (AML) patients. We earlier reported a change in the metabolic state of hematopoietic stem cells upon Gfi1b deletion....

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PMID: 35804097
DOI: 10.1038/s41375-022-01635-9

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