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Posttranslational regulation of PGC‐1α and its implication in cancer metabolism

8 Mar 2019

Abstract excerpt

Deregulation of cellular metabolism is well established in cancer. The mitochondria are dynamic organelles and act as the center stage for energy metabolism. Central to mitochondrial regulatory network is peroxisome proliferator-activated receptor γ coactivator 1a (PGC-1α), which serves as a master regulator of mitochondrial proliferation and metabolism. The activity and stability of PGC-1α are subject to dynamic...

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PMID: 30848477
DOI: 10.1002/ijc.32253

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