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The Role of PGC1α in Cancer Metabolism and its Therapeutic Implications

16 Apr 2016

Abstract excerpt

PGC1α is a transcription factor coactivator that influences a majority of cellular metabolic pathways. Abnormal expression of PGC1α is associated with several chronic diseases and, in recent years, it has been shown to be a critical controller of cancer development. PGC1α acts as a stress sensor in cancer cells and can be activated by nutrient deprivation, oxidative damage, and chemotherapy. It influences...

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PMID: 27197257
DOI: 10.1158/1535-7163.mct-15-0621

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