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Article

PGC-1 coactivators in the control of energy metabolism

17 Feb 2011

Abstract excerpt

Chronic disruption of energy balance, where energy intake exceeds expenditure, is a major risk factor for the development of metabolic syndrome. The latter is characterized by a constellation of symptoms including obesity, dyslipidemia, insulin resistance, hypertension, and non-alcoholic fatty liver disease. Altered expression of genes involved in glucose and lipid metabolism as well as mitochondrial oxidative...

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PMID: 21325336
DOI: 10.1093/abbs/gmr007

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