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Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance

29 Jun 2022

Abstract excerpt

HORMAD1 expression is usually restricted to germline cells, but it becomes mis-expressed in epithelial cells in ~60% of triple-negative breast cancers (TNBCs), where it is associated with elevated genomic instability (1). HORMAD1 expression in TNBC is bimodal with HORMAD1-positive TNBC representing a biologically distinct disease group. Identification of HORMAD1-driven genetic dependencies may uncover novel...

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PMID: 35768547
DOI: 10.1038/s41388-022-02369-9

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