Article
Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers.
Cancer discovery - 1 May 2015
Watkins Johnathan, Weekes Daniel, Shah Vandna, Gazinska Patrycja, Joshi Shalaka, Sidhu Bhavna, Gillett Cheryl, Pinder Sarah, Vanoli Fabio, Jasin Maria, Mayrhofer Markus, Isaksson Anders, Cheang Maggie C U, Mirza Hasan, Frankum Jessica, Lord Christopher J, Ashworth Alan, Vinayak Shaveta, Ford James M, Telli Melinda L, Grigoriadis Anita, Tutt Andrew N J
Abstract excerpt
UNLABELLED: Triple-negative breast cancers (TNBC) are characterized by a wide spectrum of genomic alterations, some of which might be caused by defects in DNA repair processes such as homologous recombination (HR). Despite this understanding, associating particular patterns of genomic instability with response to therapy has been challenging. Here, we show that allelic-imbalanced copy-number aberrations (AiCNA)...
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