Article

Mutational signatures of DNA mismatch repair deficiency in <i>C. elegans</i> and human cancers

2017-06-13

Abstract excerpt

<h4>ABSTRACT</h4> Throughout their lifetime cells are subject to extrinsic and intrinsic mutational processes leaving behind characteristic signatures in the genome. DNA mismatch repair (MMR) deficiency leads to hypermutation and is found in different cancer types. While it is possible to associate mutational signatures extracted from human cancers with possible mutational processes the exact causation is often u...

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Literature Corpus work: b9362915-7976-5cc9-9bce-152b46fc089c
DOI: 10.1101/149153

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