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Targeting Germline- and Tumor-Associated Nucleotide Excision Repair Defects in Cancer

16 Nov 2020

Abstract excerpt

Abstract Purpose: Nucleotide excision repair (NER) gene alterations constitute potential cancer therapeutic targets. We explored the prevalence of NER gene alterations across cancers and putative therapeutic strategies targeting these vulnerabilities. Experimental Design: We interrogated our institutional dataset with mutational data from more than 40,000 patients with cancer to assess the frequency of putative...

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PMID: 33199492
DOI: 10.1158/1078-0432.ccr-20-3322

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