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Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting

8 Apr 2024

Abstract excerpt

Homologous recombination (HR) and nucleotide excision repair (NER) are the two most frequently disabled DNA repair pathways in cancer. HR-deficient breast, ovarian, pancreatic and prostate cancers respond well to platinum chemotherapy and PARP inhibitors. However, the frequency of HR deficiency in gastric and esophageal adenocarcinoma (GEA) still lacks diagnostic and functional validation. Using whole exome and...

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PMID: 38589664
DOI: 10.1038/s41698-024-00561-6

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