Article

Loss of 18q alters TGFβ signalling affecting anteroposterior neuroectodermal fate in human embryonic stem cells

2024-10-10

Abstract excerpt

Chromosomal abnormalities acquired during cell culture can compromise the differentiation potential of human pluripotent stem cells (hPSCs). In this work, we identified a diminished differentiation capacity to retinal progenitor cells in human embryonic stem cells (hESCs) with loss of chromosome 18q. Time-course gene-expression analysis during spontaneous differentiation and single-cell RNA sequencing found that t...

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Literature Corpus work: a5a9b5eb-99a9-5aa4-af3f-e6a6c690d94a
DOI: 10.1101/2024.10.09.617397

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