Article

A dynamic <i>in vitro</i> model of Down Syndrome neurogenesis with Trisomy 21 gene dosage correction

2022-05-11

Abstract excerpt

<h4>ABSTRACT/SUMMARY</h4> Excess gene dosage from human chromosome 21 (chr21) causes Down syndrome (DS), spanning developmental as well as acute phenotypes in terminal cell types. Which phenotypes remain amenable to intervention after development is unknown. To address this question in a model of DS neurogenesis, we generated trisomy 21 (T21) human induced pluripotent stem cells (hiPSCs) alongside otherwise isoge...

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Literature Corpus work: e59de133-d705-5d3f-9435-000f41962944
DOI: 10.1101/2022.05.11.491519

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