Article
Most brain disease-associated and eQTL haplotypes are not located within transcription factor DNase-seq footprints in brain.
Human molecular genetics - 1 Jan 2017
Handel Adam E, Gallone Giuseppe, Zameel Cader M, Ponting Chris P
Abstract excerpt
Dense genotyping approaches have revealed much about the genetic architecture both of gene expression and disease susceptibility. However, assigning causality to genetic variants associated with a transcriptomic or phenotypic trait presents a far greater challenge. The development of epigenomic resources by ENCODE, the Epigenomic Roadmap and others has led to strategies that seek to infer the likely functional...
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