Article

Importin α Characterizes a Micronuclear Environment Associated with Genomic Instability in Human Cancer Cells

2023-06-07

Abstract excerpt

Micronuclei (MN) are membrane-enclosed chromatin bodies and hallmarks of genome instability. Here, we report that importin α, a key nuclear transport factor, is highly concentrated in a distinct subset of MN in cultured human cancer cells. This selective localization is not governed by classical nuclear transport pathways. Live-cell photobleaching revealed remarkably reduced mobility of importin α between MN and c...

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Literature Corpus work: 7cf540e9-43d1-5e31-8e7b-10178e55fa71
DOI: 10.1101/2023.06.06.543979

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