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Targeting nuclear import and export in hematological malignancies

5 Jul 2020

Abstract excerpt

The transport of proteins across the nuclear membrane is a highly regulated process, essential for the cell function. This transport is actively mediated by members of the karyopherin family, termed importins, or exportins, depending on the direction of transport. These proteins play an active part in tumorigenesis, through aberrant localization of their cargoes, which include oncogenes, tumor-suppressor genes...

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PMID: 32624581
DOI: 10.1038/s41375-020-0958-y

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