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Article

MitoQ alleviates m.3243A>G-induced mitochondrial dysfunction by stabilizing PINK1 and enhancing mitophagy.

Journal of genetics and genomics = Yi chuan xue bao - 1 Mar 2026

Cao Baige, Fang Lei, Zhang Yinan, Lin Chuwen, Liu Peng, Zhang Huina, Fan Orion, Xu Ming, Qin Zhao, Wang Congrong

Abstract excerpt

The mitochondrial 3243A>G mutation (m.3243A>G) is associated with diverse clinical phenotypes. To elucidate the underlying mechanisms and explore intervention strategies in m.3243A>G patients, urine-derived stem cells (USCs) and a mitochondrial leucyl-tRNA synthetase gene (lars-2) deficient Caenorhabditis elegans (C. elegans) model are used to assess mitochondrial homeostasis and neuromuscular dysfunction....

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Identifiers

PMID: 40850503
DOI: 10.1016/j.jgg.2025.08.007

Genes

PINK1
OMA1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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