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Article

Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson's disease models.

Scientific reports - 27 Nov 2017

Cooper Jason F, Machiela Emily, Dues Dylan J, Spielbauer Katie K, Senchuk Megan M, Van Raamsdonk Jeremy M

Abstract excerpt

While the pathogenesis of Parkinson's disease (PD) is incompletely understood, mitochondrial dysfunction is thought to play a crucial role in disease pathogenesis. Here, we examined the relationship between mitochondrial function and dopamine neuron dysfunction and death using C. elegans mutants for three mitochondria-related genes implicated in monogenic PD (pdr-1/PRKN, pink-1/PINK1 and djr-1.1/DJ-1). We found...

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Source

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Identifiers

PMID: 29180793
DOI: 10.1038/s41598-017-16637-2
PMCID: PMC5703891

Genes

PINK1
PRKN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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