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Article

Parkin modulates heteroplasmy of truncated mtDNA in Caenorhabditis elegans.

Mitochondrion - 1 Jan 2015

Valenci Itay, Yonai Lital, Bar-Yaacov Dan, Mishmar Dan, Ben-Zvi Anat

Abstract excerpt

Parkin, which is mutated in most recessive Parkinsonism, is a key player in the selective removal of damaged mitochondria via mitophagy. Damaged mitochondria may carry mitochondrial DNA (mtDNA) mutations, thus creating a mixed mtDNA population within cells (heteroplasmy). It was previously shown that Parkin over-expression reduced the level of heteroplasmic mutations that alter mitochondrial membrane potential in...

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Identifiers

PMID: 25462019
DOI: 10.1016/j.mito.2014.11.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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