Article

Resistance of mitochondrial DNA to chemical-induced germline mutations is independent of mitophagy in <i>C. elegans</i>

2022-03-29

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial DNA (mtDNA) is prone to mutation in aging and over evolutionary time, yet the processes that regulate the accumulation of de novo mtDNA mutations and modulate mtDNA heteroplasmy are not fully elucidated. Mitochondria lack certain DNA repair processes, which could contribute to polymerase error-induced mutations and increase susceptibility to chemical-induced mtDNA mutagenesis. We...

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Literature Corpus work: 479ea5e0-7b8e-54e1-8e84-45164fdaf02e
DOI: 10.1101/2022.03.28.486090

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