Article

Low Mutational Load Allows for High Mutation Rate Variation in Gut Commensal Bacteria

2019-03-05

Abstract excerpt

Bacteria generally live in species-rich communities, such as the gut microbiota. Yet, little is known about bacterial evolution in natural ecosystems. Here, we followed the long-term evolution of commensal Escherichia coli in the mouse gut. We observe the emergence of polymorphism for mutation rate, ranging from wild-type levels to 1000-fold higher. By combining experiments, whole-genome sequencing and in silico...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7ced794c-1c31-5d0e-96f4-d53dc323dcc5
DOI: 10.1101/568709

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Low Mutational Load Allows for High Mutation Rate Variation in Gut Commensal BacteriaDOI 10.1101/568709Read

Quantifying the adaptive landscape of commensal gut bacteria using high-resolution lineage trackingSemantic proximity Read

A Mutational Hotspot and Strong Selection Contribute to the Order of Mutations Selected for during Escherichia coli Adaptation to the Gut.Semantic proximity Read

Mutator genomes decay, despite sustained fitness gains, in a long-term experiment with bacteria.Semantic proximity Read

Costs and benefits of high mutation rates: adaptive evolution of bacteria in the mouse gut.Semantic proximity Read

Genome-wide mutational diversity in an evolving population of Escherichia coli.Semantic proximity Read

Evolution of <i>E. coli</i> in a mouse model of inflammatory bowel disease leads to a disease-specific bacterial genotype and trade-offs with clinical relevanceSemantic proximity Read

Evolution of E. coli in a mouse model of inflammatory bowel disease leads to a disease-specific bacterial genotype and trade-offs with clinical relevance.Semantic proximity Read

The role of mutational spectrum in the selection against mutator allelesSemantic proximity Read

Gnotobiotic mouse model of phage-bacterial host dynamics in the human gut.Semantic proximity Read

Escherichia coli Genomic Diversity within Extraintestinal Acute Infections Argues for Adaptive Evolution at Play.Semantic proximity Read

High mutation rates limit evolutionary adaptation in Escherichia coli.Semantic proximity Read

Evolution of the mutation rate.Semantic proximity Read