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Escherichia coli Genomic Diversity within Extraintestinal Acute Infections Argues for Adaptive Evolution at Play.

mSphere - 6 Jan 2021

Bridier-Nahmias Antoine, Launay Adrien, Bleibtreu Alexandre, Magnan Mélanie, Walewski Violaine, Chatel Jérémie, Dion Sara, Robbe-Saule Véronique, Clermont Olivier, Norel Françoise, Denamur Erick, Tenaillon Olivier

Abstract excerpt

Adaptive processes in chronic bacterial infections are well described, but much less is known about the processes at play during acute infections. Here, by sequencing seven randomly selected isolates per patient, we analyzed Escherichia coli populations from three acute extraintestinal infections in adults (meningitis, pyelonephritis, and peritonitis), in which a high-mutation-rate isolate or mutator isolate was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33408235
DOI: 10.1128/mSphere.01176-20
PMCID: PMC7845604

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